What Are Pro Hormones, like 1-Andro?
Pro hormones are substances that act as precursors to hormones, converting into active hormones within the body. They are commonly used by bodybuilders and athletes to enhance muscle mass, strength, and overall performance. When ingested, pro hormones transform into anabolic hormones, impacting various pathways in the body. The primary effects are observed on the Androgenic, Estrogenic, and Progestogenic receptors. Similar to anabolic steroids, pro hormones function as androgen receptor agonists, leading to effects associated with increased testosterone levels.
Some potential effects include:
- Increased aggression
- Enhanced sex drive
- Greater muscle strength
- Increased muscle mass
- Muscles feeling denser and more solid
However, these benefits come with an increased risk of side effects due to elevated androgen levels, such as hair loss and acne.
Pro hormones also influence estrogenic and progestogenic receptors, which can similarly support muscle mass and strength gains. However, significant muscle gains are often lost post-cycle, primarily due to water retention. This conversion process also carries its own risks, including estrogenic side effects like:
- Increased water retention
- Higher susceptibility to fat gain
- Gynecomastia (swelling of breast tissue in men)
Pro hormones are typically classified based on their primary action as androgenic, estrogenic, or both. While all pro hormones exhibit some androgenic effects, their impact on other body systems can vary.
Strong androgens are particularly effective for enhancing strength through central nervous system (CNS) stimulation, often resembling Dihydrotestosterone (DHT). Some pro hormones also boost red blood cell production, leading to larger muscle pumps and increased vascularity.
What’s Changed – Prohormones vs Steroids?
The pro hormones available today differ significantly from those before the Anabolic Steroid Control Act of 2004. Modern pro hormones feature improved delivery systems and absorption rates, reducing liver strain.
Liposomal Delivery System:
Liposomal technology, previously used in medicine, has now been incorporated into nutritional supplements. Liposomes have a hydrophobic core and a hydrophilic shell, protecting the molecule from degradation and enhancing solubility.
Cyclosome™ Delivery:
Cyclosome™ Technology is another liposomal delivery method that increases pro hormone solubility and vesicle stability. This method controls the release of pro hormones, allowing them to be delivered effectively to the systemic circulation via the intestinal lymphatic route. This avoids the “first pass effect” that renders many oral capsules and tablets ineffective.
Common Compounds:
There are various compounds and stacking methods available. This guide covers:
- Well-known compounds and their alternative names
- Potential effects
- Side effects
- Stack-ability
- Cycle lengths and types
As with any product, individual results may vary and are not guaranteed.
What Is 1-Andro?
1-Androsterone, also known as 1-DHEA, is a legal prohormone that transforms into the active steroid 1-Testosterone through a series of conversions in the body. This process involves converting 1-Andro into 1-testosterone (dihydroboldenone) and 1-androstenedione, which are positional isomers of testosterone and androstenedione. The primary muscle-building benefits come from the conversion to dihydroboldenone.
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What To Expect From 1-Andro
1-Andro is well-researched and popular for its benefits. It generally helps increase lean muscle mass, enhance strength, and boost aggression, making it a favored supplement for both bulking and cutting phases.
For bulking, products with higher concentrations of 1-Andro, like 1-Testosterone, are recommended for faster results. Conversely, formulas like 1-AD may be better for cutting due to their slower breakdown. Although the label states it has 75mg of 1-Andro, it actually contains 75mg of 1-Andro Decanoate, which yields 47 mg of 1-Andro due to an additional ester chain that helps regulate hormonal fluctuations.
These products may also contain supplementary ingredients. For example, 1-Testosterone includes grapefruit extract to slow the breakdown of 1-Andro, while 1-AD incorporates laxogenin for joint support and anabolic effects without hormonal impact. Laxogenin, a plant steroid, is non-hormonal and can be used by women to improve strength, recovery, and joint pain. However, in this formula, you may only notice joint support from laxogenin.
Chosen 1 from Blackstone Labs is a blend containing both esters and unesterified 1-Andro/1-DHEA, offering the benefits of both 1-Testosterone and 1-AD at a lower dose.
Differences Between Hi-Tech 1-AD and 1-Testosterone
- Hi-Tech 1-AD: Converts to 1-Testosterone and is a milder hormone, providing cleaner gains and significant strength increases. It suits those seeking a balanced muscle gain and strength approach.
- Hi-Tech 1-Testosterone: With its unique 1,2-double bond structure in the A ring (as opposed to the 4,5-double bond in standard testosterone), it is metabolized differently. This modification means it cannot be converted to estrogen via aromatase nor into DHT, making it a stable molecule resistant to most traditional metabolism routes. It is often referred to as a “dry” compound, suitable for both cutting and bulking phases due to its strength benefits.
1-Andro Side Effects
As with any prohormone, users should be aware of potential side effects, which may include acne, hair loss, prostate growth, cardiovascular issues, increased liver and kidney values, and testicular atrophy. Some individuals may also experience low libido and lethargy, although these effects typically subside during post-cycle therapy (PCT).
Since 1-Andro only affects androgenic receptors, estrogenic side effects are not expected. However, side effects like acne and hair loss are more likely if you are already susceptible to them.
Treating Side Effects
To mitigate potential side effects, it is recommended to take an on-cycle support supplement like Gear Support. These products help reduce the risk of side effects and should be taken with your chosen prohormones and stopped during your PCT. For low libido, you can try supplements like D-Aspartic Acid, Maca, Horny Goat Weed, or blends like Score! XXL.
Additionally, taking a multivitamin with B Vitamins can help with skin and hair care. Fish Oil, Omega 3, or NAC can benefit your whole body, hair, and skin. For acne prevention, consider using over-the-counter cleansers.
How To Cycle 1-Andro
1-Andro is usually taken in cycles lasting up to 8 weeks, followed by a 4-week post-cycle therapy (PCT) phase. Since one bottle typically lasts for 4 weeks, you’ll need a second bottle to complete an 8-week cycle.
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